In public health it is still common to see that they use the RPR test to try to diagnose new cases of syphilis. I have found that it is very common to see people clearly infected with this bacterium who are surprisingly negative in the most typical test, which is called RPR, and that is why I recommend a test that specifically looks for the antibodies of an active infection.
Dr. Jun described that this phenomenon is more prominent in people over 34 years of age and in the early stages of infection (for example primary syphilis), and in my own study on this issue I saw that a quarter of cases of the Syphilis is not detected if you only use the RPR as a diagnostic test. If you have doubts about the correct diagnosis of syphilis, I can help you because I have many years of experience.
You can read my post by clicking the button below.
Chapman S et al. Superior detection of syphilis with the rapid test DETERMINE compared with combined cardiolipin- and treponemal-specific tests.Point Care 2015 Sep; Vol 14 (3): 92-94.
Jun L, He-Yi Z. Characteristics of patients with primary and latent syphilis patients who were initially non-reactive to the rapid plasma reagin test. Jpn J Infect Dis . 2013; 66 (1): 36-40. doi: 10.7883 / yoken.66.36